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platelet-rich plasma + insulin
- Development stage
- Unknown
- Lead developer
- Amin Javer
- Modality
- Peptides, Recombinant Proteins and Enzymes
- Administration
- Intranasal, Topical
01
Overview
This investigational combination therapy consists of intranasally administered autologous platelet-rich plasma (PRP) and topical insulin. It is currently being evaluated by Dr. Amin Javer for the treatment of post-inflammatory anosmia, a condition characterized by persistent loss of smell following viral or inflammatory insults. The therapy leverages the regenerative potential of PRP, which contains high concentrations of growth factors such as platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF), alongside the neurotrophic and anti-inflammatory properties of insulin. By targeting the olfactory epithelium and olfactory neurons, the combination aims to promote neuroregeneration and restore olfactory function. The treatment is administered as a biologic modality where PRP is applied intranasally and insulin is applied topically to the olfactory cleft.
- Other names
- Intranasal PRP Plus Topical InsulinPRP + insulinIntranasal Platelet-rich Plasma Plus Topical Insulin
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)VEGFR (VEGFR family)INSR (Insulin receptor)PDGFRA (Platelet-derived growth factor receptor alpha)
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