platelet rich plasma + tissue stromal vascular fraction + cellular stromal vascular fraction

This is a **combination autologous biologic therapy** comprised of three components derived from a patient's own tissues: - **Platelet Rich Plasma (PRP):** A small volume of plasma with a high concentration of platelets containing major growth factors such as PDGF, bFGF, EGF, VEGF, IGF-1, and TGF-β. These induce angiogenesis, stimulate undifferentiated stem cell proliferation, and promote cell differentiation for tissue regeneration and wound healing[3][5][6]. - **Tissue Stromal Vascular Fraction (tissue SVF):** Heterogeneous cells isolated directly from adipose (fat) tissue, including adipose-derived stem cells (ADSCs), endothelial cells, pericytes, immune cells, and extracellular matrix. These cells have roles in angiogenesis, vasculogenesis, and tissue repair[1][5]. - **Cellular Stromal Vascular Fraction (cellular SVF):** The cellular portion of SVF, typically separated from the extracellular matrix, rich in ADSCs and regenerative cells that support neovascularization and tissue repair[1][5]. The combined therapy harnesses the synergy of PRP’s growth factors (promoting regenerative signaling and inflammation control) and SVF’s stem/progenitor cells (enabling direct tissue regeneration and repair). This combination is used in **regenerative medicine** for indications such as chronic wounds, burns, orthopedic injuries, osteoarthritis, and potentially cardiovascular and neurological disorders. Its mechanism involves both **paracrine signaling via growth factors and direct cellular replacement/regeneration**[3][5].

Other names

platelet-rich plasma + tissue SVF + cellular SVFPRP + tissue SVF + cellular SVFPRP + stromal vascular fraction (SVF)