Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
platelet-rich plasma and fibrin clot (PRGF-System)
- Development stage
- Phase 2
- Lead developer
- BTI Biotechnology Institute
- Modality
- Cell Therapies
- Administration
- Intralesional
01
Overview
Platelet-rich plasma and fibrin clot processed with the PRGF-System (Plasma Rich in Growth Factors) is an autologous biologic therapy derived from the patient's own peripheral blood. Developed using proprietary technology from BTI Biotechnology Institute, the system concentrates platelets and growth factors to produce both a liquid platelet-rich plasma fraction and a polymerized fibrin clot. These components are applied intralesionally to promote tissue repair, wound healing, and local immunomodulation. The therapy is currently being investigated in Phase II clinical trials, notably by Fundación FISEVI in Spain, for the treatment of complex perianal fistulas in patients with Crohn's disease. Its mechanism of action involves the local release of endogenous growth factors, including PDGF, TGF-β, VEGF, and EGF, which stimulate cellular proliferation and extracellular matrix synthesis.
- Brand names
- PRGF-SystemEndoret
- Other names
- Plasma Rich in Growth FactorsPRGFautologous platelet-rich plasma and fibrin clot
Beyond the preview
Go deeper on platelet-rich plasma and fibrin clot (PRGF-System).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on platelet-rich plasma and fibrin clot (PRGF-System).