platinum + cyclophosphamide

**Platinum + cyclophosphamide** is a combination chemotherapy regimen that includes a platinum-based agent (usually either *cisplatin* or *carboplatin*) and *cyclophosphamide*. Cyclophosphamide is an alkylating agent of the nitrogen mustard type that is metabolized in the liver to active compounds, which crosslink DNA and prevent cancer cell division and proliferation[1][4]. Platinum compounds (such as cisplatin or carboplatin) form DNA adducts and crosslinks, leading to cytotoxicity primarily through the inhibition of DNA replication and transcription. The combination is used for the treatment of various malignancies, including ovarian cancer and breast cancer, as well as other solid tumors. The regimen is antineoplastic, working by directly damaging the DNA in cancer cells, thereby inhibiting cell growth and division[1][7]. The combination is administered intravenously, with dosing and scheduling dependent on cancer type and protocol.