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platinum azidothymidine
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
Platinum azidothymidine (Pt-AZT) is a **synthetic platinum-based compound** derived from the antiretroviral drug azidothymidine (AZT) and a platinum moiety. It is designed to combine the anticancer activity of platinum compounds (like cisplatin) with the telomerase-inhibiting property of AZT. Pt-AZT reduces telomerase activity and Bcl-2 expression in cancer cells, which promotes apoptosis and suppresses tumor growth. Preclinical studies in rat models of hepatocellular carcinoma have shown that Pt-AZT is more effective than AZT alone in decreasing both telomerase activity and Bcl-2 concentration, thereby inhibiting cancer progression and metastasis. Its mechanism of action targets cancer cell proliferation through apoptosis induction and telomerase inhibition. This compound has been investigated primarily for anticancer effects, especially in hepatocellular carcinoma[1][3].
- Other names
- platin-3-azido-2,3-dideoxythymidine
02
Targets
BCL-2 (BCL-2 family)TERT (Telomerase)
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