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PLCB4 shRNA
- Development stage
- Preclinical
- Lead developer
- Aichi Cancer Center
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
PLCB4 shRNA is a short hairpin RNA (shRNA) designed to silence the expression of phospholipase C beta 4 (PLCB4). In research models of malignant mesothelioma, PLCB4 was identified as a gene up-regulated by the Yes-associated protein (YAP) following Hippo pathway disruption (e.g., NF2 deletion). Silencing PLCB4 using shRNA has been shown to attenuate the growth of YAP-transduced mesothelial cells and Hippo-disrupted mesothelioma cell lines, suggesting that PLCB4 is a critical mediator of YAP-driven cell proliferation and a potential therapeutic target for mesothelioma.
- Other names
- phospholipase C beta 4 shRNAshRNA-mediated silencing of PLCB4
02
Targets
PI-PLC (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4)
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