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**Plectranthus amboinicus extract** is a herbal extract derived from the leaves and aerial parts of *Plectranthus amboinicus*, an aromatic perennial herb in the Lamiaceae family. It is widely used in traditional medicines across Africa, Asia, and India for conditions such as cough, asthma, skin diseases, digestive ailments, headaches, fever, and epilepsy[2][3][5]. Pharmacological studies have reported antimicrobial, antifungal, anti-inflammatory, antitumor, antioxidant, antidiabetic, analgesic, and diuretic activities[1][2][3][4][5]. Mechanistically, its extracts can inhibit the NLRP3 inflammasome pathway in vitro and reduce release of inflammatory mediators (e.g., caspase-1, IL-1β, IL-18), likely via partial inhibition of p65 NF-κB, ASC oligomerization, and potassium efflux[4]. Key bioactive phytochemicals identified include monoterpenoids (such as linalool, carvacrol), diterpenoids, triterpenoids, sesquiterpenoids, phenolics (notably rosmarinic acid), and flavonoids[2][4][5].
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