Drug intelligence / Profile preview

plectranthus amboinicus extract

Development stage
Preclinical
Lead developer
Oneness Biotech
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

**Plectranthus amboinicus extract** is a herbal extract derived from the leaves and aerial parts of *Plectranthus amboinicus*, an aromatic perennial herb in the Lamiaceae family. It is widely used in traditional medicines across Africa, Asia, and India for conditions such as cough, asthma, skin diseases, digestive ailments, headaches, fever, and epilepsy[2][3][5]. Pharmacological studies have reported antimicrobial, antifungal, anti-inflammatory, antitumor, antioxidant, antidiabetic, analgesic, and diuretic activities[1][2][3][4][5]. Mechanistically, its extracts can inhibit the NLRP3 inflammasome pathway in vitro and reduce release of inflammatory mediators (e.g., caspase-1, IL-1β, IL-18), likely via partial inhibition of p65 NF-κB, ASC oligomerization, and potassium efflux[4]. Key bioactive phytochemicals identified include monoterpenoids (such as linalool, carvacrol), diterpenoids, triterpenoids, sesquiterpenoids, phenolics (notably rosmarinic acid), and flavonoids[2][4][5].

Other names
Indian borage extractcountry borage extractMexican mint extractCuban oregano extract
02

Targets

RELA (Nuclear Factor Kappa B Subunit p65)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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