Pleozymes

Pleozymes are pleiotropic oxidized carbon nanozymes designed as synthetic redox mediators to enhance the metabolic resilience and persistence of CAR T cell therapies, particularly in solid tumors. These 3-8 nm nanoparticles are synthesized from coconut-derived activated charcoal and exhibit mitochondrial localization. They function by mimicking multiple enzymatic activities, including superoxide dismutase (SOD)-like scavenging and NADH/NAD+ interconversion. By modulating the redox environment, Pleozymes restore bioenergetic flexibility, concurrently activating glycolysis, fatty acid beta-oxidation, and the tricarboxylic acid (TCA) cycle. In preclinical models of hepatocellular carcinoma, treatment with Pleozymes reduced T cell exhaustion markers (TIM-3 and LAG-3) and promoted differentiation into stem cell memory (TSCM) and central memory (TCM) phenotypes, thereby improving antitumor efficacy.

Other names

pleiotropic oxidized carbon nanozymesoxidized carbon nanoparticles