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Pleurotus ostreatus ethanolic extract
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Pleurotus ostreatus ethanolic extract (PoEE) is a natural extract derived from the edible oyster mushroom (*Pleurotus ostreatus*). It is primarily investigated in preclinical models for its chemopreventive, antineoplastic, and metabolic properties. PoEE has been shown to exert potent anticancer effects, particularly in hormone receptor-positive breast cancer, by modulating the PI3K/Akt/mTOR signaling pathway. It downregulates key oncogenic components such as PI3K, Akt, mTOR, Ras, and MAPK, while restoring tumor suppressors like PTEN, GSK3β, and FOXO. Additionally, PoEE exhibits anti-obesity potential by suppressing PPARγ expression and maintaining PPARγ promoter methylation during adipocyte differentiation, as well as protecting cells from glycemic and oxidative stress.
- Other names
- PoEEoyster mushroom ethanolic extract
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)PPARG (Peroxisome proliferator-activated receptor gamma)mTOR (Mammalian target of rapamycin kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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