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PLK1 shRNA
- Development stage
- Preclinical
- Lead developer
- University of Wisconsin-Madison
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
PLK1 shRNA (Polo-like kinase 1 short hairpin RNA) is a genetic tool used to knock down the expression of the PLK1 gene through RNA interference (RNAi). PLK1 is a serine/threonine kinase that plays a critical role in cell cycle regulation, particularly during mitosis. Overexpression of PLK1 is associated with various malignancies, including melanoma, where it promotes cell proliferation, survival, and epithelial-mesenchymal transition (EMT). By delivering shRNA sequences that are complementary to PLK1 mRNA, researchers can induce the degradation of the transcript, leading to reduced PLK1 protein levels. This approach is widely used in preclinical research to validate PLK1 as a therapeutic target and to study its involvement in tumor progression and metastasis.
- Other names
- Polo-like kinase 1 short hairpin RNAshPLK1shPLK-1shPLK 1
02
Targets
PLK1 (Polo like kinase 1)
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