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PLX-821

Development stage: Preclinical
Lead developer: ProLynx
Modality: Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Subcutaneous

Overview

PLX-821 is an ultra-long-acting, subcutaneous sustained-release formulation of semaglutide being developed by ProLynx for the treatment of obesity and type 2 diabetes. The therapeutic candidate utilizes ProLynx's proprietary tetra-PEG-based hydrogel microsphere platform and tunable linker chemistry to form a stable subcutaneous depot. This system gradually releases native semaglutide over an extended period without a burst release, enabling a once-monthly dosing interval. By acting as a glucagon-like peptide-1 (GLP-1) receptor agonist, PLX-821 promotes insulin secretion, suppresses glucagon release, and delays gastric emptying to regulate blood glucose and reduce body weight.

Other names: MS + Semaglutide

Targets

GLP1R (GLP-1R)

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