Drug intelligence / Profile preview

PM1015

Development stage
Phase 1
Lead developer
BioNTech
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

PM1015 is a monoclonal antibody that specifically targets CD73 (ecto-5'-nucleotidase), functioning as a CD73 inhibitor. By inhibiting CD73, which plays a role in the production of immunosuppressive adenosine in the tumor microenvironment, PM1015 aims to enhance anti-tumor immune responses. The drug is being developed primarily for the treatment of advanced solid tumors and liver cancer. It is currently undergoing phase 1 clinical trials to evaluate its safety, pharmacokinetics, and preliminary efficacy in patients with advanced malignant solid neoplasms[1][2][3][5]. The developer and active organization for this drug is Biotheus.

Other names
anti-CD73 monoclonal antibodyanti-CD-73 monoclonal antibodyanti-CD 73 monoclonal antibodyCD73 AntigenCD-73 AntigenCD 73 Antigen
02

Targets

NT5E (Cluster of Differentiation 73)

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