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pMMP-2 siRNA
- Development stage
- Preclinical
- Lead developer
- University of Illinois Chicago
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
pMMP-2 siRNA (also referred to as pM.si) is a plasmid-based small interfering RNA (siRNA) designed to silence the expression of Matrix Metalloproteinase-2 (MMP-2). In preclinical studies focusing on glioblastoma multiforme (GBM), pMMP-2 siRNA has been shown to inhibit endothelial cell proliferation and angiogenesis. The mechanism involves the downregulation of MMP-2, which subsequently reduces IL-3 expression and inhibits the Jak2/Stat5 signaling pathway. It also disrupts the interaction between MMP-2 and integrin α5β1. This therapeutic approach aims to serve as an anti-angiogenic treatment for high-grade gliomas.
- Other names
- MMP-2 siRNAMMP2 siRNAMMP 2 siRNA
02
Targets
MMP2 (Matrix metalloproteinase-2)
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