Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
PNA1
- Development stage
- Unknown
- Lead developer
- ProNeurogen
- Modality
- Peptides
- Administration
- Subcutaneous
01
Overview
PNA1 is a peptide-based therapeutic candidate developed by ProNeurogen, currently in Phase 1 clinical trials for the treatment of vascular dementia, traumatic brain injury (TBI), and post-operative cognitive impairment. As part of ProNeurogen's neurovascular program, PNA1 functions as an agonist of the Mas receptor (MasR), a G protein-coupled receptor that mediates the neuroprotective and anti-inflammatory effects of the alternative renin-angiotensin system (RAS) pathway. By targeting the MasR, PNA1 is designed to improve cognitive function, reduce neuroinflammation, and enhance cerebral blood flow in patients with neurovascular disorders. The drug is a formulation of the endogenous peptide Angiotensin-(1-7), which is known to counteract the vasoconstrictive and pro-inflammatory effects of the classical Angiotensin II/AT1 receptor axis.
- Other names
- Angiotensin-(1-7)
02
Targets
MAS1 (Mas receptor)
Beyond the preview
Go deeper on PNA1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PNA1.