PNC-27

PNC-27 is a synthetic anticancer peptide consisting of residues 12-26 of the p53 protein (the MDM2-binding domain) conjugated to a cell-penetrating peptide (penetratin) derived from the Antennapedia homeodomain of Drosophila. Unlike traditional p53-based therapies that aim to restore p53's transcriptional activity, PNC-27 acts by binding to MDM2 proteins expressed specifically on the surface of cancer cells. This binding induces the formation of transmembrane pores, leading to rapid, selective membrane disruption and necrotic cell death, independent of the cell's p53 status. It has been studied in various solid tumors, including pancreatic, breast, and fibrosarcoma models, demonstrating selectivity for malignant cells over their untransformed counterparts.

Other names

p53-derived peptide 12-26-penetratinp-53-derived peptide 12-26-penetratinp 53-derived peptide 12-26-penetratin