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PnCJ + PPS
- Development stage
- Discontinued
- Lead developer
- Inserm
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
PnCJ + PPS is a combination vaccine strategy that utilizes both a conjugated anti-pneumococcal vaccine (PnCJ) and a polysaccharide anti-pneumococcal vaccine (PPS). This "prime-boost" approach is designed to enhance immunogenicity compared to the use of the polysaccharide vaccine alone. The combination has been studied in patients with common variable immunodeficiency, aiming to improve immune response against Streptococcus pneumoniae by leveraging both T-cell dependent (conjugate) and T-cell independent (polysaccharide) mechanisms[1][2]. The developer involved in clinical studies is Institut National de la Santé Et de la Recherche Médicale, France.
02
Targets
BCR-CPS (B cell receptor specific for Streptococcus pneumoniae capsular polysaccharide epitopes)MHC II (Major histocompatibility complex class II receptor)
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