Drug intelligence / Profile preview

pneumococcal 13-valent conjugate vaccine (CanSino Biologics Inc.)

Development stage
Unknown
Lead developer
Pfizer
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

PCV13 vaccine, specifically the 13-valent pneumococcal polysaccharide conjugate vaccine developed by CanSino Biologics (often designated as PCV13i), is a conjugate vaccine indicated for the prevention of invasive pneumococcal disease caused by *Streptococcus pneumoniae*. It targets 13 common serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. The vaccine works by conjugating these bacterial capsular polysaccharides to a carrier protein, CRM197, which enhances the immune response by engaging T-cells, making it effective in infants and young children. CanSino's formulation was designed to optimize the manufacturing process and improve the stability and immunogenicity of the vaccine. It received marketing approval from the China National Medical Products Administration (NMPA) in April 2024 for use in infants and children.

Brand names
WeigancaiPrevnar 13Prevnar13Prevnar-13
Other names
13-valent pneumococcal polysaccharide conjugate vaccine13-valent pneumococcal conjugate vaccinePneumococcal 13-valent conjugate vaccine (diphtheria CRM197 protein)
02

Targets

CPS 18C (Streptococcus pneumoniae capsular polysaccharide serotype 18C)PPS5 (Streptococcus pneumoniae capsular polysaccharide serotype 5)CPS19F (Streptococcus pneumoniae capsular polysaccharide serotype 19F)CPS4 (Streptococcus pneumoniae capsular polysaccharide serotype 4)7F CPS (Streptococcus pneumoniae serotype 7F capsular polysaccharide)PPS3 (Streptococcus pneumoniae serotype 3 capsular polysaccharide)19A CPS (Streptococcus pneumoniae serotype 19A capsular polysaccharide)Streptococcus pneumoniae capsular polysaccharide serotype 6BCPS14 (Streptococcus pneumoniae capsular polysaccharide serotype 14)CPS23F (Streptococcus pneumoniae capsular polysaccharide serotype 23F)Streptococcus pneumoniae capsular polysaccharide serotype 9V (PnPS 9V)6A CPS (Streptococcus pneumoniae serotype 6A capsular polysaccharide)SpCPS1 (Streptococcus pneumoniae capsular polysaccharide serotype 1)

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