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pneumococcal 21-valent conjugate vaccine
- Development stage
- Approved
- Lead developer
- Merck
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Capvaxive (V116) is a 21-valent pneumococcal conjugate vaccine developed by Merck (MSD) for the prevention of invasive pneumococcal disease and pneumococcal pneumonia in adults. Approved by the FDA in June 2024, it is specifically designed to cover the serotypes responsible for approximately 84% of invasive pneumococcal disease in adults aged 65 and older. The vaccine includes eight unique serotypes (15A, 15C, 16F, 23A, 23B, 24F, 31, and 35B) that are not covered by other currently licensed pneumococcal vaccines. Capvaxive consists of purified capsular polysaccharides from 21 *Streptococcus pneumoniae* serotypes, each individually conjugated to a CRM197 carrier protein. This conjugation enhances the immune response by converting T-cell independent polysaccharide antigens into T-cell dependent antigens, thereby inducing immunological memory and higher antibody titers. The vaccine is administered as a single intramuscular injection and does not contain an adjuvant.
- Brand names
- Capvaxive
- Other names
- PCV21PCV-21PCV 21Pneumococcal 21-valent Conjugate VaccinePneumococcal21-valent Conjugate VaccinePneumococcal-21-valent Conjugate Vaccine
02
Targets
CPS (Streptococcus pneumoniae capsular polysaccharide)
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