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pneumococcal conjugate vaccine
- Development stage
- Approved
- Lead developer
- Pfizer
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Pneumococcal conjugate vaccine is a type of pneumococcal vaccine that contains purified capsular polysaccharides from Streptococcus pneumoniae serotypes chemically linked (conjugated) to a carrier protein, typically CRM197 (a non-toxic variant of diphtheria toxin). This conjugation enhances immunogenicity, making it effective in children under 2 years old, unlike plain polysaccharide vaccines. The vaccine works by stimulating antibody production against pneumococcal capsular polysaccharides, enabling opsonophagocytic killing of the bacteria.
- Brand names
- PrevnarPrevnar 13Prevnar13Prevnar-13
- Other names
- PCVPCV7PCV-7PCV 7PCV13PCV-13PCV 13
02
Targets
CPS (Streptococcus pneumoniae capsular polysaccharide)
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