pneumococcal polysaccharide serotype 33F

Pneumococcal polysaccharide serotype 33F is a specific capsular antigen used in the development of vaccines against *Streptococcus pneumoniae*. Developed by Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), this antigen targets serotype 33F, which has emerged as a significant cause of invasive pneumococcal disease following the introduction of earlier conjugate vaccines like PCV13. The antigen is typically a purified polysaccharide or a synthetic oligosaccharide designed to mimic the natural capsule. When administered, it stimulates the immune system to produce opsonophagocytic antibodies that recognize and facilitate the destruction of the bacteria. This candidate is part of a broader effort to expand the serotype coverage of pneumococcal vaccines to address serotype replacement and provide more comprehensive protection against pneumonia, meningitis, and bacteremia.

Other names

Streptococcus pneumoniae serotype 33F capsular polysaccharidePneumococcal serotype 33F antigen