pneumococcal polysaccharide serotype 4

Pneumococcal polysaccharide serotype 4 refers to the specific capsular carbohydrate antigen derived from *Streptococcus pneumoniae* serotype 4. In the context of development at Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), research has focused on the chemical synthesis of well-defined oligosaccharides that mimic the natural polysaccharide structure. These synthetic antigens are typically conjugated to a carrier protein, such as CRM197, to enhance their immunogenicity and induce a T-cell dependent immune response, which is particularly important for providing protection in infants and the elderly. The goal of this synthetic approach is to create more consistent, high-purity vaccine candidates that can be manufactured with greater precision than traditional methods involving the purification of polysaccharides from bacterial cultures. This antigen is designed to protect against invasive pneumococcal diseases, including pneumonia, meningitis, and bacteremia caused by serotype 4.

Other names

Streptococcus pneumoniae serotype 4 capsular polysaccharideSp4Sp-4Sp 4pneumococcal polysaccharide type 4