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Drug intelligence / Profile preview
pneumococcal vaccine-GlaxoSmithKline-diphtheria-tetanus-pertussis-hepatitis B-poliomyelitis-Haemophilus influenzae type b infection-meningococcal C disease
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The drug name refers to a combination immunization regimen developed by GSK, consisting of an investigational heptavalent vaccine (GSK2202083A) and a 10-valent pneumococcal conjugate vaccine (Synflorix). GSK2202083A is designed to protect against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, *Haemophilus influenzae* type b (Hib), and meningococcal C (MenC). Synflorix (GSK1024850A) provides protection against 10 serotypes of *Streptococcus pneumoniae*. This co-administered regimen was evaluated in Phase 2 clinical trials in healthy infants to assess safety and immunogenicity when given as a three-dose primary course. The approach aims to simplify the pediatric vaccination schedule by providing broad protection against eight major childhood diseases in a single visit.
- Brand names
- Synflorix
- Other names
- GSK2202083A + SynflorixDTPa-HBV-IPV/Hib-MenC + PCV10
02
Targets
FHA (Filamentous hemagglutinin)HBsAg (Hepatitis B surface antigen)Neisseria meningitidis group C capsular polysaccharidePRN (Pertactin)CPS (Streptococcus pneumoniae capsular polysaccharide)TT (Tetanus toxoid)Poliovirus type 1 capsid proteinWPV3 (Poliovirus type 3 capsid protein)
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