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PNID

Development stage
Preclinical
Modality
Small Molecules, Peptides
01

Overview

**PNID** is a highly non-specific acronym that refers to several distinct entities in medical and scientific literature, including two drug candidates, multiple disease categories, and a psychological assessment tool. As a drug, **PNID** primarily refers to: 1) **chi-conotoxin PnID** (or **PnID**), a novel peptide isolated from the venom of the marine snail *Conus pennaceus* that acts as a selective inhibitor of the **norepinephrine transporter (NET)**, currently being researched for the treatment of **neuropathic pain** and other neurological disorders; and 2) **Paning I decoction (PNID)**, a traditional Chinese herbal formula investigated for its neuroprotective effects in **Parkinson's disease**. The decoction's mechanism involves reducing neuroinflammation by inhibiting fibrinogen deposition, modulating microglial polarization from the pro-inflammatory M1 state to the anti-inflammatory M2 state, and repairing the blood-brain barrier. Beyond these drugs, PNID is a common abbreviation for **Pediatric Neuroimmunological Disorders**, **Pulmonary Non-Infectious Disease**, and the **Peer Nomination Inventory of Depression** (a scale used to evaluate childhood depression).

Other names
chi-conotoxin PnIDPaning I decoctionχ-conotoxin PnID
02

Targets

NET (Norepinephrine Transporter)

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