PNOC031 regimen

The PNOC031 regimen is a comprehensive treatment protocol developed by the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and the University of California, San Francisco (UCSF) specifically for children with newly diagnosed Embryonal Tumor with Multilayered Rosettes (ETMR), a rare and aggressive pediatric brain tumor. The protocol utilizes a multi-modal approach that includes surgical resection followed by intensive induction chemotherapy, high-dose chemotherapy with autologous stem cell rescue, and focal radiation therapy. The chemotherapy component is a multi-agent regimen consisting of various antineoplastic drugs assigned based on physician choice and standard of care, typically including DNA alkylators, antimetabolites, and microtubule inhibitors to target the rapidly dividing tumor cells through multiple cytotoxic pathways.

Other names

UCSF ETMR chemotherapy protocolPNOC031 protocolPNOC-031 protocolPNOC 031 protocol