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PNS-anthrax vaccine
- Development stage
- Preclinical
- Lead developer
- Aphios
- Modality
- Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
**PNS-anthrax vaccine** is an Aphios preclinical anthrax vaccine formulation based on recombinant *Bacillus anthracis* protective antigen encapsulated in biodegradable polymer nanospheres manufactured using the company's solvent-minimizing SuperFluids PNS technology. The nanosphere carrier is intended to provide controlled antigen release and adjuvant activity, potentially enhancing antigen uptake and immune stimulation. In a preliminary mouse immunization study, a lyophilized rPA polymer-nanosphere preparation designated rPA-01 was formulated with Alhydrogel and administered intramuscularly before anthrax-spore challenge. ([aphios.com](https://www.aphios.com/products/therapeutic-products-pipeline/infectious-disease/vaccine-adjuvant-technology/anthrax-vaccine-adjuvant/))
- Other names
- Anthrax Vaccine AdjuvantrPA-01rPA01rPA 01
02
Targets
PA (Influenza polymerase acidic protein)
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