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POL-6

Development stage: Unknown
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

POL-6 is a standardized polyherbal preparation composed of dried extracts from six medicinal plants: *Bacopa monnieri*, *Hypericum perforatum*, *Centella asiatica*, *Withania somnifera*, *Camellia sinensis*, and *Ocimum sanctum* in a specific ratio (2:1:2:2:1:2). It is primarily investigated for its therapeutic potential in treating ethanol withdrawal-induced anxiety and alcohol dependence. The preparation contains bioactive phytoconstituents such as withaferin A, quercetin, catechin, rutin, caffeic acid, and β-sitosterol. Mechanistically, POL-6 appears to normalize GABAergic neurotransmission by modulating the mRNA expression of GABAA receptor subunits in the amygdala and hippocampus, thereby exerting anxiolytic effects during alcohol withdrawal.

Other names: standardized polyherbal preparation POL-6

Targets

GABRA2 (Gamma-aminobutyric acid receptor subunit alpha 2)

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