Drug intelligence / Profile preview

Polimmune

Development stage
Unknown
Lead developer
Ourofino Saúde Animal
Modality
MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration
Intramuscular, Subcutaneous
01

Overview

Polimmune is a veterinary immunostimulant and antiviral agent primarily composed of polyinosinic-polycytidylic acid (Poly I:C). It functions as a synthetic analog of double-stranded RNA (dsRNA), acting as a potent agonist of Toll-like receptor 3 (TLR3) and other pattern recognition receptors such as MDA5. By mimicking a viral infection, Polimmune induces the production of Type I interferons (IFN-alpha and IFN-beta) and activates various components of the innate and adaptive immune systems, including natural killer (NK) cells and macrophages. It is used in veterinary medicine to enhance the immune response to vaccines and to assist in the treatment of viral diseases in livestock and companion animals. The drug is particularly established in the South American veterinary market for species including cattle, horses, and dogs.

Brand names
Polimmune
Other names
Polyinosinic-polycytidylic acidPolyinosinic:polycytidylic acid
02

Targets

IFIH1 (MDA5)TLR3 (Toll-like receptor 3)

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