Drug intelligence / Profile preview

polipillV2

Development stage: Unknown
Lead developer: Hospital do Coração São Paulo
Modality: Small Molecules
Administration: Oral

Overview

PolipillV2 is an experimental fixed-dose combination (polypill) developed by Hospital do Coração (HCor) in Brazil for the prevention and management of cardiovascular disease. It contains four active ingredients: aspirin (75 mg), simvastatin (40 mg), lisinopril (10 mg), and hydrochlorothiazide (12.5 mg). This combination targets multiple cardiovascular risk factors simultaneously, including platelet aggregation, cholesterol levels, and blood pressure. It was investigated in the SPACE (Single Pill to Avert Cardiovascular Events) trial to evaluate its efficacy in improving treatment compliance and reducing cardiovascular risk compared to usual care.

Brand names: Red Heart Pill
Other names: Red Heart Pill

Targets

ACE (Angiotensin Converting Enzyme)PGHS-1 (Prostaglandin G/H Synthase 1)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

Beyond the preview

Go deeper on polipillV2.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on polipillV2.

Explore the full profile