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PoliVal-ICP
- Development stage
- Unknown
- Lead developer
- Instituto Clodomiro Picado
- Modality
- Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
PoliVal-ICP is a liquid polyvalent antivenom developed and manufactured by the **Instituto Clodomiro Picado (ICP)** of the University of Costa Rica. It is a hyperimmune equine serum containing purified polyclonal antibodies (IgG) designed to neutralize the toxins found in the venom of Central and South American vipers, specifically from the genera *Bothrops*, *Crotalus*, and *Lachesis*. The antivenom is indicated for the treatment of snakebite envenomation (ophidism) and is approved for use in several countries in the region. It works by binding to venom components such as metalloproteinases and phospholipases A2, preventing them from interacting with their physiological targets and causing systemic or local damage.
- Brand names
- PoliVal-ICP
- Other names
- Suero antiofídico polivalentePolivalent antivenom (ICP)Liquid hyperimmune serum (ICP)
02
Targets
SV-LAAO (Snake venom L-amino acid oxidase)svPLA2 (Snake venom phospholipase A2)SVMP (Snake venom metalloproteinase)
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