Drug intelligence / Profile preview

Pollinex Quattro Grass

Development stage
Unknown
Lead developer
Allergy Therapeutics
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

Pollinex Quattro Grass is an ultra-short course, subcutaneous allergy immunotherapy vaccine developed for the treatment of grass pollen allergy, including seasonal allergic rhinitis and seasonal allergic rhinoconjunctivitis. The formulation consists of chemically modified (glutaraldehyde-treated) grass pollen allergens adsorbed onto a L-tyrosine depot and combined with the novel adjuvant monophosphoryl lipid A (MPL). This combination aims to enhance efficacy by promoting T helper cell activity while maintaining a favorable safety profile. The MPL adjuvant acts as a Toll-like receptor 4 (TLR4) agonist, boosting immune response and desensitization to allergens. The regimen requires only four preseasonal injections, offering improved patient compliance compared to traditional immunotherapies. Clinical studies have demonstrated significant reductions in symptoms and medication use with good tolerability[2][3][5][8].

Brand names
Pollinex Quattro Grass
Other names
Grass MATA MPLPQ Grass 27600 SU
02

Targets

Phleum pratense allergensTLR4 (Toll-like receptor 4)

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