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Pollinex Quattro Plus Birch
- Development stage
- Unknown
- Lead developer
- Allergy Therapeutics
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
Pollinex Quattro Plus Birch is an ultra-short-course subcutaneous immunotherapy (SCIT) developed by Allergy Therapeutics for the treatment of seasonal allergic rhinitis and rhinoconjunctivitis caused by birch pollen. The formulation consists of glutaraldehyde-modified birch pollen extract (allergoids) adsorbed onto L-tyrosine, which acts as a slow-release depot, and is adjuvanted with Monophosphoryl Lipid A (MPL). MPL is a Toll-like receptor 4 (TLR4) agonist that enhances the Th1-mediated immune response, shifting the balance away from the Th2 response associated with allergy. This combination allows for a shorter dosing regimen (typically four injections) compared to traditional immunotherapy.
- Brand names
- Pollinex Quattro Plus Birch
- Other names
- PQ Birch 200
02
Targets
TLR4 (Toll-like receptor 4)
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