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PolTREG CAR-Treg therapy
- Development stage
- Preclinical
- Lead developer
- PolTREG
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous, Intrathecal
01
Overview
PolTREG's CAR-Treg therapy is an autologous engineered cell therapy being developed for the treatment of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). The therapy utilizes the patient's own regulatory T cells (Tregs), which are engineered with chimeric antigen receptors (CARs) to specifically target and suppress pathological immune responses in neuroinflammatory diseases. By directing Tregs to the site of inflammation, the therapy aims to restore immune homeostasis and prevent further neurodegeneration. As of late 2024, the program is in preclinical development, with plans for first-in-human trials in 2025. The therapy is designed for both systemic and intrathecal administration.
- Other names
- CAR-TregCAR Tregschimeric antigen receptor regulatory T cells
02
Targets
CD6
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