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poly-ICLC + peptide-pulsed dendritic cells
- Development stage
- Unknown
- Lead developer
- Medical University of South Carolina
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal, Intramuscular
01
Overview
A combination investigational cancer vaccine regimen consisting of autologous dendritic cells (DCs) pulsed with defined tumor-associated antigen peptides, administered together with the toll-like receptor 3 agonist poly-ICLC (stabilized polyinosinic-polycytidylic acid with poly-L-lysine and carboxymethylcellulose). The DC component presents class I–restricted peptides to prime tumor-specific CD8 T cells, while poly-ICLC acts as an immune adjuvant to enhance DC activation and type I interferon–driven innate and adaptive responses. In a phase I study in HLA-A2 positive pancreatic adenocarcinoma, DCs were pulsed with peptides from hTERT, CEA, and survivin; the regimen was safe and induced measurable antigen-specific T cells, with some patients achieving stable disease.[3][1][2]
- Other names
- poly(IC:LC) + peptide-pulsed autologous dendritic cells
02
Targets
IFIH1 (MDA5)MHC I (MHC class I})TLR3 (Toll-like receptor 3)
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