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poly-l-lysine G3 + vitamin A

Development stage
Preclinical
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Topical
01

Overview

Poly-l-lysine G3 + vitamin A is a combination dermocosmetic formulation that includes third-generation poly-L-lysine dendrigraft (G3) and vitamin A. Poly-L-lysine is a synthetic cationic polymer known for its biocompatibility and ability to enhance the stability, penetration, and efficacy of co-administered active ingredients. Vitamin A (retinol or its derivatives) is widely used in dermatology for its role in skin cell turnover, repair, and anti-inflammatory effects. This combination has been studied as part of a sequential skincare regimen for atopic dermatitis, where it was applied in the evening after a morning application of poly-L-lysine G2/vitamin C. The product aims to provide natural, plant-derived active ingredients suitable for sensitive or atopic skin by leveraging the synergistic properties of both components to improve hydration, barrier function, and clinical symptoms such as pruritus and inflammation[1]. Clinical studies have shown significant improvements in Dermatology Life Quality Index (DLQI) and SCORAD scores after 28 days of use[1].

Other names
poly-L-lysine dendrigraft G3 + vitamin Apoly-L-lysine G3/vitamin A
02

Targets

RARA (Retinoic acid receptor alpha)

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