Poly-Tussin

Poly-Tussin is a combination pharmaceutical product developed by **Poly Pharmaceuticals** (also known as Poli Pharmaceutics) for the symptomatic relief of cough and upper respiratory symptoms associated with the common cold, rhinitis, or allergies. It is a multi-ingredient small molecule formulation typically containing **hydrocodone bitartrate**, **chlorpheniramine maleate**, and **phenylephrine hydrochloride**. Hydrocodone acts as a potent antitussive by suppressing the cough reflex in the medullary cough center of the brain. Chlorpheniramine is a first-generation antihistamine that antagonizes H1 receptors to alleviate allergic symptoms such as sneezing and rhinorrhea. Phenylephrine serves as a decongestant by stimulating alpha-1 adrenergic receptors, leading to vasoconstriction of the nasal mucosa and reduction of nasal congestion. The product is marketed as a prescription liquid for oral administration.

Brand names

Poly-TussinPoly Tussin

Other names

Hydrocodone bitartrate + chlorpheniramine maleate + phenylephrine hydrochloride