Drug intelligence / Profile preview

Poly-Vent

Development stage
Unknown
Lead developer
Poly Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Poly-Vent is a brand name for a line of combination oral medications developed and marketed by Poly Pharmaceuticals (also known as Poly Pharmaceutics) for the symptomatic relief of upper respiratory conditions. The product line includes multiple formulations: Poly-Vent IR, which contains the expectorant guaifenesin and the nasal decongestant pseudoephedrine HCl; and Poly-Vent DM, which adds the cough suppressant dextromethorphan HBr. These small molecule drugs work through multiple mechanisms: pseudoephedrine acts as a sympathomimetic agent on alpha- and beta-adrenergic receptors to reduce nasal congestion, guaifenesin helps loosen phlegm and thin bronchial secretions to facilitate chest congestion relief, and dextromethorphan suppresses the cough reflex. These medications are FDA-approved and indicated for the temporary relief of symptoms associated with the common cold, hay fever (allergic rhinitis), and other upper respiratory allergies, including nasal congestion, cough, and chest congestion.

Brand names
Poly-VentPoly-Vent IRPoly-Vent DM
02

Targets

ADRA1 (Alpha-1 adrenergic receptor family)NMDAR (Glutamate receptor ionotropic, NMDA)SIGMAR1 (Sigma non-opioid intracellular receptor 1)ADRB1 (β1)

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