polyacrylamide hydrogel

Polyacrylamide hydrogel is a synthetic, three-dimensional, cross-linked polymer network made from polyacrylamide and water, typically consisting of about 2.5% cross-linked polyacrylamide and 97.5% nonpyrogenic water[2]. It is known for its high water absorption capacity, biocompatibility, and mechanical adaptability, mimicking the properties of natural living tissues[1]. This hydrogel is widely utilized as a biomaterial in medical devices, wound dressings, controlled drug delivery systems, and implants[1][2][3]. Its mechanism of action centers on absorbing water by forming hydrogen bonds (osmosis), maintaining a moist environment for wound healing, and serving as a tunable matrix for controlled release of incorporated therapeutics[1][2]. Polyacrylamide-based hydrogels also act as anti-fouling coatings for implants, reducing foreign body response and local inflammation[3]. The hydrogel can be further tailored in composition and physical structure to optimize porosity, mechanical strength, and biocompatibility for specific biomedical uses[3]. It is nonresorbable, stable, and exhibits low toxicity[2].

Brand names

NoltrexNoltrex VetNoltrex®Vet

Other names

polyacrylamide-based hydrogelPAAm hydrogelpoly(acrylamide) hydrogel