polyallylamine bisphosphonate

Polyallylamine bisphosphonate (PAB) is a synthetic polymer-drug conjugate consisting of a polyallylamine backbone functionalized with bisphosphonate groups. It is primarily investigated in preclinical research for two distinct therapeutic applications: bone-targeted drug delivery and phosphate sequestration. The bisphosphonate moieties exhibit a high affinity for hydroxyapatite, the primary mineral component of bone, allowing the polymer to serve as a bone-seeking carrier for various therapeutic payloads, such as anti-inflammatory or anti-neoplastic agents. This targeting mechanism is intended to improve the treatment of bone-related disorders like osteoporosis and bone metastases while minimizing systemic side effects. Additionally, PAB has been explored as a high-capacity phosphate binder for the management of hyperphosphatemia in patients with chronic kidney disease (CKD). In this context, the compound acts within the gastrointestinal tract to bind dietary phosphate through ionic interactions, preventing its absorption into the bloodstream.

Other names

polyallylamine biphosphonatebisphosphonated polyallylaminepoly(allylamine bisphosphonate)