polyethylene glycol + bisacodyl

Polyethylene glycol (PEG) + bisacodyl is a combination bowel preparation regimen used to cleanse the colon prior to medical procedures such as colonoscopy. In the context of clinical research at the Hospital Universitario de Canarias (specifically the REPREP2 trial), this regimen involves an intensive high-volume approach consisting of 4 liters of PEG solution administered in split doses, supplemented with the stimulant laxative bisacodyl and a three-day fiber-free diet. Polyethylene glycol acts as an osmotic laxative, increasing the water content and volume of stool to stimulate bowel movements. Bisacodyl is a diphenylmethane derivative that acts as a stimulant laxative by directly affecting the colonic mucosa and the myenteric plexus to increase peristalsis. This specific combination is being evaluated for its efficacy in patients identified as having a high risk of poor colonic cleansing based on validated predictive scores.

Brand names

LoVol-esseLovoldyl

Other names

4 L polyethylene glycol solution plus bisacodylIntensive high-volume bowel cleansing regimenPEG + bisacodyl