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polyethylene glycol + senna
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Polyethylene glycol + senna is a combination of two laxatives used primarily for bowel preparation before colonoscopy and for the treatment of constipation. Polyethylene glycol (PEG) acts as an osmotic laxative, retaining water in the stool to soften it and increase stool frequency. Senna is a stimulant laxative that contains sennosides, which irritate the lining of the bowel to stimulate intestinal motility and promote defecation. The combination aims to improve patient tolerance by reducing PEG volume while maintaining effective bowel cleansing, with studies showing non-inferior efficacy compared to high-volume PEG regimens but with fewer side effects such as nausea and bloating[3][5]. Both agents are approved for over-the-counter use individually; their combination is commonly used in clinical practice for colonoscopy preparation.
- Brand names
- PursennidEx-LaxLaxabon
- Other names
- senna + pegsenna plus polyethylene glycolPEG-senna combination
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