Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
polyethylene glycol + sennosides
- Development stage
- Unknown
- Lead developer
- Braintree
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Polyethylene glycol (PEG) and sennosides (senna) are established laxative agents used in the management of opioid-induced constipation (OIC). Polyethylene glycol is an osmotic laxative that works by drawing water into the intestinal lumen, thereby softening the stool and facilitating its passage. Sennosides are stimulant laxatives derived from the senna plant; they are hydrolyzed by gut bacteria into active metabolites that stimulate the myenteric plexus and increase colonic motility. The British Columbia Cancer Agency (BCCA) evaluated these two treatments in a randomized, double-blind, crossover clinical trial involving cancer outpatients. The study aimed to compare the efficacy and tolerability of a stepped bowel protocol using these agents, providing evidence for their use as first-line treatments for OIC in palliative care settings.
- Brand names
- SenokotMiraLAXRestoraLAXGlycoLax
- Other names
- polyethylene glycol + sennaPEG + sennaPEG + sennosides
Beyond the preview
Go deeper on polyethylene glycol + sennosides.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on polyethylene glycol + sennosides.