polyethylene glycol + simethicone

Polyethylene glycol (PEG) + simethicone is a combination therapy used for bowel cleansing prior to gastrointestinal procedures such as colonoscopy and capsule endoscopy. Polyethylene glycol acts as an osmotic laxative, inducing a watery diarrhea that clears the colon of fecal matter. Simethicone is a non-absorbable surfactant that acts as an antifoaming agent by reducing the surface tension of gas bubbles in the digestive tract. This reduction in bubbles improves mucosal visualization, particularly in the right colon, and may reduce patient symptoms like bloating and abdominal discomfort. Clinical trials have demonstrated that the addition of simethicone to standard PEG regimens (ranging from 2L to 4L) significantly improves bubble scores and mucosal visibility without compromising the safety or tolerability of the preparation.

Other names

PEG + simethiconepolyethylene glycol plus simethiconePEG-ELS + simethicone