Drug intelligence / Profile preview

polyethylene glycol 400 + propylene glycol + dextran + hypromellose

Development stage
Unknown
Lead developer
Alcon
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Ophthalmic
01

Overview

This drug is a combination ophthalmic formulation containing polyethylene glycol 400, propylene glycol, dextran, and hypromellose. It is used as an artificial tear or eye lubricant to relieve symptoms of dry eyes such as burning, irritation, and discomfort. Each component acts as a demulcent or humectant to moisten the ocular surface and form a protective layer over the mucous membrane of the eye. Polyethylene glycol 400 and propylene glycol are polyol demulcents that help retain moisture on the ocular surface[5][7][8]. Dextran and hypromellose (also known as hydroxypropyl methylcellulose) are polysaccharide polymers that further enhance viscosity and prolong retention time on the cornea[2][5]. The combination works by supplementing natural tears, reducing evaporation from the eye surface, protecting against environmental irritants, and providing symptomatic relief for dry eye conditions.

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