polyethylene glycol 400 + propylene glycol + hydroxypropyl-guar

This drug is a combination ophthalmic formulation containing polyethylene glycol 400 (PEG 400), propylene glycol, and hydroxypropyl-guar. It is used as an artificial tear or lubricant eye drop for the temporary relief of burning and irritation due to dry eyes. Polyethylene glycol 400 and propylene glycol act as lubricants that mimic natural tears to moisten the ocular surface and reduce symptoms of dryness[1][2][7]. Hydroxypropyl-guar is a derivative of guar gum that acts as a viscosity-enhancing agent; it forms a gel-like matrix on the eye surface which helps stabilize the tear film and prolongs retention time of the lubricants[6]. The combination restructures and stabilizes all three layers of the tear film (mucin, aqueous, lipid), reduces evaporation/drainage of tears, provides symptomatic relief from environmental or medical causes of dry eye disease[7].

Brand names

Systane Gel DropsSystane Preservative-FreeSystane Lubricant Eye DropsSystane Ultra Preservative-Free

Other names

PEG 400 + propylene glycol + hydroxypropyl-guarPEG-400/propylene glycol/hydroxypropyl guar ophthalmic solution