polyethylene glycol 4000 + simethicone

This is a bowel preparation regimen consisting of polyethylene glycol (PEG) 4000 and simethicone, specifically evaluated for small bowel cleansing in pediatric patients undergoing capsule endoscopy. PEG 4000 acts as an osmotic laxative to clear the bowel of fecal matter by increasing water content in the intestinal lumen, while simethicone serves as an anti-foaming agent to reduce air bubbles that can interfere with endoscopic visualization. The regimen was studied in the PREP-CE trial by Azienda Policlinico Umberto I (Sapienza University of Rome), where it was found to be the most successful preparation regimen, improving visualization particularly in the distal ileum and reducing patient discomfort compared to other cleansing methods.

Brand names

Panamir

Other names

PEG 4000 + simethiconepolyethylene glycol 4000 solution with simethicon