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Polyethylene glycol loxenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist used primarily for the treatment of type 2 diabetes mellitus. It is derived from exendin-4 and modified with polyethylene glycol (PEG) to enhance its pharmacokinetic properties. This modification increases its half-life and reduces immunogenicity, allowing for once-weekly administration. It is also being explored for its potential effects on weight management and cardiovascular outcomes.
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