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polyglactin 910 + triclosan
- Development stage
- Unknown
- Lead developer
- Ethicon
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Device-based Delivery → Drug Delivery Systems, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Surgical Implant
01
Overview
Polyglactin 910 + triclosan is a specialized surgical suture material that combines absorbable polyglactin 910 with the antimicrobial agent triclosan. The triclosan component inhibits bacterial colonization on the suture surface by blocking the enzyme enoyl-ACP reductase (Fab I gene), which prevents the biosynthesis of bacterial fatty acids. This antimicrobial action is effective against both gram-positive and gram-negative bacteria commonly associated with surgical site infections. Clinical studies have demonstrated that these sutures can significantly reduce the risk of surgical site infections compared to conventional sutures.
- Brand names
- Coated VICRYL Plus AntibacterialVICRYL Plus
- Other names
- Triclosan-coated polyglactin 910 sutureAntibacterial triclosan-coated polyglactin 910 suture
02
Targets
FabK (Enoyl-acyl carrier protein reductase FabK)
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