polymerized grass pollen extract

**Polymerized grass pollen extract** is a chemically modified allergen extract used for subcutaneous immunotherapy (SCIT) in patients with grass pollen-induced allergic rhinoconjunctivitis. It consists of a standardized mixture of six grasses (Holcus lanatus, Dactylis glomerata, Lolium perenne, Phleum pratense, Poa pratensis, Festuca elatior) and rye pollen (Secale cereale), treated with glutardialdehyde to polymerize the allergens, reducing IgE reactivity and enabling rapid cluster up-dosing schedules. Adsorbed onto aluminum hydroxide, it is administered subcutaneously, achieving maintenance doses (e.g., 5000 TU) quickly, with demonstrated efficacy in reducing symptom and medication scores by 36-43% in phase III trials, alongside immunological effects like increased specific IgG4.[1][2]

Brand names

CLUSTOID

Other names

high polymerized grass pollen extractglutardialdehyde-modified high polymerized allergen extractglutardialdehyde-polymerized allergen extract