polymyxin B nonapeptide + N-formylmethionyl-leucyl-phenylalanine

This combination consists of **polymyxin B nonapeptide** and **N-formylmethionyl-leucyl-phenylalanine**, an experimental pairing used in mechanistic immunology and host-pathogen studies rather than as an approved therapeutic product. Polymyxin B nonapeptide is a deacylated polymyxin B derivative that binds bacterial lipopolysaccharide and permeabilizes the outer membrane of Gram-negative bacteria without the full bactericidal activity of polymyxin B, while N-formylmethionyl-leucyl-phenylalanine is a prototypical formyl peptide receptor agonist that activates neutrophils and other phagocytes, promoting chemotaxis and respiratory burst responses. In combination, the pair has been used experimentally to sensitize Gram-negative bacteria to neutrophil-mediated killing and to probe how outer-membrane disruption cooperates with innate immune cell activation. No evidence was identified that this exact combination is an approved pharmaceutical drug or a named clinical development candidate.

Other names

polymyxin B nonapeptide + N-formylmethionyl-leucyl-phenylalaninePMBN + fMLPpolymyxin B nonapeptide + fMLP