polymyxin b sulfate + gramicidin + neomycin

Polymyxin b sulfate + gramicidin + neomycin is an established **triple-combination ophthalmic antibiotic** small-molecule drug product used for the topical treatment of superficial bacterial infections of the external eye and its adnexa, including blepharitis, blepharoconjunctivitis, conjunctivitis, keratitis, and keratoconjunctivitis. The formulation combines three antibacterial agents with complementary mechanisms: **neomycin** is an aminoglycoside that inhibits bacterial protein synthesis by binding the 30S ribosomal subunit, while **polymyxin B** and **gramicidin** disrupt the bacterial cytoplasmic membrane, increasing permeability and causing leakage of intracellular contents. It is marketed as an ophthalmic solution, commonly at **1.75 mg neomycin sulfate, 10,000 units polymyxin B sulfate, and 0.025 mg gramicidin per mL**, under brands such as Neosporin Ophthalmic Solution; it is a long-established prescription product and is also available as a generic formulation rather than a novel proprietary asset.

Brand names

Neosporin Ophthalmic SolutionNeocidinAK-SporeNeocin PGNeopticOcu-Spore-G

Other names

neomycin + polymyxin b sulfate + gramicidinneomycin and polymyxin b sulfates and gramicidin ophthalmic solutionpolymyxin b sulfate + gramicidin + neomycin ophthalmic solution